Vet-Recommended · Rx & OTC

Flea & Tick Prevention, delivered with care.

Flea and tick prevention keeps your pet protected from parasites year-round. PetMeds carries 10 vet-recommended products — oral chews like NexGard, Bravecto, and Simparica Trio for dogs, and topical treatments like Revolution Plus and Advantage II for cats. Prescription options are verified by a licensed PharmD before shipping. Save 15% with AutoShip.

10Vet-recommended products
50States shipped to
15%AutoShip savings
2.3MFamilies served
A happy dog outdoors — flea and tick protection delivered

Every prescription verified by a licensed PharmD

Reviewed by Dr. Sarah Chen, PharmD
  • Licensed Pharmacy
  • Vet Recommended
  • HIPAA Compliant
  • Free Ship $49+
  • 30-Day Returns
  • 30 Years Trusted
Quick Answer

What is the best flea and tick treatment for dogs and cats?

The best flea and tick treatment depends on your pet's species, weight, lifestyle, and any known conditions. For dogs, vet-recommended options include NexGard Chewable, Bravecto Chewable, Simparica Trio, and Credelio — all oral, all effective for 30+ days. For cats, topical options like Revolution Plus, Advantage II, and Bravecto Plus are the vet standard. Never use a dog flea product on a cat.

Reviewed by Dr. Sarah Chen, PharmD Licensed pharmacist · University of Florida College of Pharmacy · Last reviewed October 9, 2026
Signature Interactive

How do I find the right flea and tick treatment for my pet?

Answer three questions about your pet — species, size, and any known concerns — and the PetMeds treatment finder will match you to the flea and tick products most farm and ranch families start with, ranked by fit for your pet's profile.

Step 1 of 3 — What kind of pet?

Step 2 of 3 — What's their size?

Step 3 of 3 — Anything we should know?

Here's what we recommend.

Based on your pet's profile, these products match best.

Why 30-Day Dosing Matters

What is the flea life cycle?

The flea life cycle has four stages — egg, larva, pupa, and adult. Only the adult stage lives on your pet. The other three stages live in your environment: carpet, bedding, and cracks. A single female flea can lay 50 eggs per day. The pupa stage can survive dormant for 6 months. This is why skipping a monthly dose can trigger a new infestation — and why consistent 30-day protection is the vet standard.

Seasonal Risk

When is flea and tick season?

Flea season runs year-round in warm climates and peaks in late summer. Tick season is more seasonal — ticks are most active from spring through fall, but many species remain active any day above 40°F. Year-round prevention is the safest approach, especially in rural and warm-climate regions.

Tap any month to see the risk level and what's active. Dogs are outdoors more often, so peak tick season (April–October) matters most. Fleas breed indoors year-round — keep protection consistent even in winter.
Shop Flea & Tick

What flea and tick products does PetMeds carry?

PetMeds carries 10 vet-recommended flea and tick products for dogs and cats. For dogs: NexGard Chewable, Bravecto Chewable, Simparica Trio, Frontline Plus, Seresto Collar, and Credelio Chewable. For cats: Revolution Plus, Advantage II, Bravecto Plus, and Cheristin. Six are prescription, four are over-the-counter. AutoShip saves 15% on every recurring order.

Rx · #1 Best Seller NexGard Chewable for dogs
Flea & Tick · Dogs

NexGard Chewable — 3 Month Supply

Monthly oral chewable · Beef flavor · 4.8–60 lb dosing tiers

4.9 · 8,420 reviews
$89.99 $119.99
AutoShip $76.49
Rx · 12-Week Bravecto Chewable for dogs
Flea & Tick · Dogs

Bravecto Chewable — 3 Month Supply

12-week oral chewable · Pork flavor · Single dose protection

4.8 · 6,210 reviews
$119.99
AutoShip $101.99
Rx · Combo Simparica Trio for dogs
Flea & Tick + Heartworm · Dogs

Simparica Trio — 3 Month Supply

Flea, tick, and heartworm in one monthly chew

4.9 · 4,180 reviews
$109.99
AutoShip $93.49
OTC Frontline Plus topical flea and tick treatment
Flea & Tick · Dogs

Frontline Plus Topical — 3 Month Supply

Monthly topical · Kills fleas, ticks, and chewing lice · No Rx

4.7 · 12,140 reviews
$49.99
AutoShip $42.49
OTC · 8-Month Seresto Flea and Tick Collar for dogs
Flea & Tick · Dogs

Seresto Flea & Tick Collar — 8 Month

Long-lasting collar · Odorless · Water-resistant

4.6 · 9,850 reviews
$64.99
AutoShip $55.24
Rx Credelio Chewable for dogs
Flea & Tick · Dogs

Credelio Chewable — 3 Month Supply

Monthly oral chewable · Beef-flavored · Fast flea kill

4.8 · 3,420 reviews
$89.99
AutoShip $76.49
Rx · Cat #1 Revolution Plus topical for cats
Flea & Tick + Heartworm · Cats

Revolution Plus — 3 Month Supply

Monthly topical · Flea, tick, and heartworm prevention

4.9 · 5,180 reviews
$59.99
AutoShip $50.99
OTC Advantage II topical flea treatment for cats
Flea · Cats

Advantage II Topical — 4 Month Supply

Fast-acting topical · Kills fleas on contact · No Rx

4.7 · 7,290 reviews
$49.99
AutoShip $42.49
Rx · 2-Month Bravecto Plus topical for cats
Flea & Tick · Cats

Bravecto Plus Topical — 2 Month Supply

Extended topical · Flea, tick, and heartworm protection

4.8 · 2,840 reviews
$79.99
AutoShip $67.99
OTC Cheristin topical flea treatment for cats
Flea · Cats

Cheristin Topical — 3 Month Supply

Fast topical · Kills fleas in 30 minutes · No Rx

4.7 · 3,120 reviews
$44.99
AutoShip $38.24
Signature Interactive

How much flea and tick medication does my pet need?

Flea and tick medication dosage is based on your pet's weight, not age. Enter your pet's weight and select the species, and the calculator shows the correct dose tier for the most popular products, plus projected annual cost with AutoShip.

Recommended Dose Tier
Medium
for pets 20–50 lb
NexGard tierMedium
Annual cost (AutoShip)$305
Multi-year savings$1,080
Safety First

What should I check before giving my pet flea and tick medication?

Flea and tick medication is safe when matched correctly to your pet. These five checks prevent the most common errors — and every PetMeds pharmacist is available at 1-800-738-6337 if you have a question.

Never use a dog product on a cat. Permethrin — found in many dog flea products — is highly toxic to cats and can be fatal. Always use cat-specific flea and tick products.
Match dose to weight, not age. Dosing is based on your pet's current weight. If your puppy or kitten is between size thresholds, ask your vet before choosing.
Check for known conditions. Some products interact with medications or are not recommended for pets with liver, kidney, or seizure conditions. Every PetMeds prescription is reviewed by a licensed PharmD before shipping.
Watch the first 24 hours. Some pets experience mild reactions — drooling, mild lethargy, or topical application-site irritation. Contact your vet if reactions last more than 24 hours.
Pregnant, nursing, or very young pets. Age minimums vary by product (most require 8 weeks and 4 lb). Call 1-800-738-6337 to speak with a pharmacist about your specific pet.
Quick Answers

Quick answers about flea and tick prevention

Short, direct answers to the questions pet parents ask most.

How often should I give flea and tick treatment?
Most monthly flea and tick treatments should be applied every 30 days. Some products like Bravecto offer up to 12 weeks of protection in a single dose. Always follow the manufacturer's instructions for the specific product.
Can I use dog flea medication on my cat?
No. Never use dog flea medication on cats. Many ingredients safe for dogs — like permethrin — are highly toxic to cats and can be fatal. Always use cat-specific flea and tick products.
Do indoor pets need flea and tick prevention?
Yes. Indoor pets still need flea and tick prevention because fleas and ticks can enter your home on clothing, shoes, and other pets. Indoor-only cats and dogs are still at risk.
What's the best flea treatment for dogs with sensitive skin?
For dogs with sensitive skin, oral flea treatments like NexGard, Bravecto, Simparica, or Credelio are often preferred over topical treatments. They avoid skin irritation and are highly effective.
How long can fleas live without a host?
Adult fleas can live 1–2 weeks without a host, but flea eggs and pupae can survive in the environment for up to 6 months. This is why environmental treatment matters as much as treating the pet — a flea pupa can wait out the winter and hatch the moment it senses a host.
When is flea and tick season?
Flea season runs year-round in warm climates and peaks in late summer. Tick season is more seasonal — ticks are most active from spring through fall, but many species remain active any day above 40°F. Year-round prevention is the safest approach.
Do I need a prescription for flea and tick medication?
Only for prescription flea and tick medications like NexGard, Bravecto, Simparica, or Revolution Plus. Over-the-counter options like Frontline Plus, Advantage II, and Seresto collars don't require a prescription.
How does AutoShip work for flea and tick medication?
AutoShip is PetMeds' subscription program. Choose how often you want each product delivered — every 30, 60, or 90 days — and we handle the rest. You save 15% on every AutoShip order, shipping is always free, and you can skip, delay, change, or cancel any shipment from your account with one click.
What if my pet has fleas in the house?
Treat every pet in the household on a monthly preventive — 95% of a flea infestation lives in the environment (carpet, bedding, baseboards), not on the pet. Wash all bedding in hot water, vacuum daily for two weeks, and treat carpets and upholstery. Consistency is the only way to break the cycle.
Which flea treatment is safe for puppies and kittens?
Age and weight minimums vary by product. NexGard is approved for puppies 8 weeks and older, weighing 4+ lb. Frontline Plus is approved for puppies and kittens 8 weeks and older. Always check the label and consult your vet for pets under 8 weeks. Call 1-800-738-6337 to speak with a pharmacist on duty.
More Questions, Answered

What else should I know about flea and tick prevention?

Consistency beats catching up. 95% of a flea infestation lives in the environment, not on the pet. Treat every pet monthly, wash bedding in hot water, vacuum daily for two weeks. AutoShip re-enters the pipeline every 30 days so you never miss a dose. Call 1-800-738-6337 to speak with a pharmacist about your pet.

Yes — briefly. Flea preventives don't repel fleas; they kill them after they bite. So a new flea can land on your pet, bite, and die within hours. As long as every pet in the household is on a monthly preventive, the cycle breaks and infestations can't establish.

No. Fleas breed indoors year-round — a warm house is a perfect environment. And flea pupae can lie dormant for up to 6 months, hatching the moment temperatures rise. Skipping winter doses is the #1 cause of spring reinfestation.

Some natural products (diatomaceous earth, cedar oil) can support environmental control, but they're not a substitute for a vet-recommended preventive. Speak with your vet before relying on natural-only approaches — the flea life cycle is too resilient.

Some flea and tick products interact with other medications or are not recommended for pets with specific conditions. When you order through PetMeds, every prescription is reviewed by a licensed PharmD before it ships — that's how we catch interactions before they happen.

Part the fur between the shoulder blades (where your pet can't lick it) and apply the full dose directly to skin — not on the fur. Hold for a moment to let it absorb. Keep pets and children from touching the site for 24 hours while it dries.
Built on Real Systems

What systems power PetMeds flea and tick orders?

Six core systems power every PetMeds order: the OMS order pipeline, Ordergroove for subscriptions, the Vet Portal for prescription verification, Iterable for customer messaging, Salesforce Service Cloud for support cases, and the PIM for product data. Prescriptions for flea and tick products like NexGard and Bravecto are verified by a licensed PharmD before shipping.

OMSOrder hub
OrdergrooveSubscription engine
Vet PortalRx verification
MiddlewareEvent routing
SFSCCustomer service
IterableRetention
Reviewed by Dr. Sarah Chen, PharmD Licensed pharmacist specializing in veterinary pharmacy · Last reviewed October 9, 2026

Protect Your Pet Year-Round

Start with AutoShip and save 15% on every recurring order — plus free shipping on every shipment, no minimum.